Changes in HIV RNA viral load, CD4+ T‐cell counts, and levels of immune activation markers associated with anti‐tuberculosis therapy and cotrimoxazole prophylaxis among HIV‐infected tuberculosis patients in Abidjan, Côte d'Ivoire
Identifieur interne : 000F00 ( Main/Exploration ); précédent : 000E99; suivant : 000F01Changes in HIV RNA viral load, CD4+ T‐cell counts, and levels of immune activation markers associated with anti‐tuberculosis therapy and cotrimoxazole prophylaxis among HIV‐infected tuberculosis patients in Abidjan, Côte d'Ivoire
Auteurs : Mireille Kalou [Côte d'Ivoire] ; Madeleine Sassan-Morokro [Côte d'Ivoire] ; Lucien Abouya [Côte d'Ivoire] ; Célestin Bile [Côte d'Ivoire] ; Chantal Maurice [Côte d'Ivoire] ; Mathieu Maran [Côte d'Ivoire] ; Odette Tossou [Côte d'Ivoire] ; Thierry Roels [Côte d'Ivoire, Géorgie (pays)] ; Alan E. Greenberg [Côte d'Ivoire, Géorgie (pays)] ; Stefan Z. Wiktor [Côte d'Ivoire, Géorgie (pays)] ; John N. Nkengasong [Côte d'Ivoire, Géorgie (pays), États-Unis]Source :
- Journal of Medical Virology [ 0146-6615 ] ; 2005-02.
English descriptors
- KwdEn :
- Abidjan, African patients, Becton dickinson, Blood donors, Ccr5, Cote, Cotrimoxazole, Cotrimoxazole group, Cotrimoxazole treatment, Coulibaly, Disease control, Disease progression, Horizontal lines, Human virus, Human virus type, Immune, Immune activation, Immune activation markers, Marker, Median, Median levels, Median plasma, Mycobacterium tuberculosis, Neopterin, Outlier values, Placebo, Placebo group, Plasma samples, Pulmonary tuberculosis, Rank test, Regimen, Standard regimens, Standard treatment, Successful treatment, Treatment regimens, Tuberculosis, Tuberculosis patients, Tuberculosis therapy, Tumor necrosis factor, Viral, Viral load, Virus type, Wilcoxon, Wilcoxon test.
- Teeft :
- Abidjan, African patients, Becton dickinson, Blood donors, Ccr5, Cote, Cotrimoxazole, Cotrimoxazole group, Cotrimoxazole treatment, Coulibaly, Disease control, Disease progression, Horizontal lines, Human virus, Human virus type, Immune, Immune activation, Immune activation markers, Marker, Median, Median levels, Median plasma, Mycobacterium tuberculosis, Neopterin, Outlier values, Placebo, Placebo group, Plasma samples, Pulmonary tuberculosis, Rank test, Regimen, Standard regimens, Standard treatment, Successful treatment, Treatment regimens, Tuberculosis, Tuberculosis patients, Tuberculosis therapy, Tumor necrosis factor, Viral, Viral load, Virus type, Wilcoxon, Wilcoxon test.
Abstract
We analyzed changes in plasma human immunodeficiency virus (HIV)‐1 viral load, CD4+ T‐cell count, and markers of immune activation markers at start of treatment of tuberculosis and 12 months after among 44 HIV‐1‐infected patients with newly diagnosed, sputum‐smear positive for Mycobacterium tuberculosis pulmonary in fection. All patients received a standard regimen of 6 months of rifampicin and isoniazid with first 2 months of pyrazinamid with or without cotrimoxazole. Compared with values at start of treatment, median viral load increased by a median of 0.64 log10 copies/ml after 12 months of follow‐up (P = 0.0002). Median CD4+ T‐cell counts were 393 cells/L at start of treatment and 370 cells/L after 12 months of follow‐up (P = 0.61). Levels of serum activation markers decreased significantly at 12 months of follow‐up of the patients for both patients on standard and cotrimoxazole treatment. Levels of viral load, CD4+ T‐cell counts, and markers of immune activation were not different for patients on standard treatment of tuberculosis compared with those on standard and cotrimoxazole treatment. Levels of serum activation markers decreased significantly at 12 months of follow‐up of the patients for both patients on standard and cotrimoxazole treatment. Because viral load is a predictor of disease progression, its persistent elevated levels in blood of HIV‐infected patients co‐infected with tuberculosis, who successfully complete TB treatment, may account for the high mortality observed in this population. J. Med. Virol. 75:202–208, 2005. © 2004 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jmv.20257
Affiliations:
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Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Abidjan</term>
<term>African patients</term>
<term>Becton dickinson</term>
<term>Blood donors</term>
<term>Ccr5</term>
<term>Cote</term>
<term>Cotrimoxazole</term>
<term>Cotrimoxazole group</term>
<term>Cotrimoxazole treatment</term>
<term>Coulibaly</term>
<term>Disease control</term>
<term>Disease progression</term>
<term>Horizontal lines</term>
<term>Human virus</term>
<term>Human virus type</term>
<term>Immune</term>
<term>Immune activation</term>
<term>Immune activation markers</term>
<term>Marker</term>
<term>Median</term>
<term>Median levels</term>
<term>Median plasma</term>
<term>Mycobacterium tuberculosis</term>
<term>Neopterin</term>
<term>Outlier values</term>
<term>Placebo</term>
<term>Placebo group</term>
<term>Plasma samples</term>
<term>Pulmonary tuberculosis</term>
<term>Rank test</term>
<term>Regimen</term>
<term>Standard regimens</term>
<term>Standard treatment</term>
<term>Successful treatment</term>
<term>Treatment regimens</term>
<term>Tuberculosis</term>
<term>Tuberculosis patients</term>
<term>Tuberculosis therapy</term>
<term>Tumor necrosis factor</term>
<term>Viral</term>
<term>Viral load</term>
<term>Virus type</term>
<term>Wilcoxon</term>
<term>Wilcoxon test</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Abidjan</term>
<term>African patients</term>
<term>Becton dickinson</term>
<term>Blood donors</term>
<term>Ccr5</term>
<term>Cote</term>
<term>Cotrimoxazole</term>
<term>Cotrimoxazole group</term>
<term>Cotrimoxazole treatment</term>
<term>Coulibaly</term>
<term>Disease control</term>
<term>Disease progression</term>
<term>Horizontal lines</term>
<term>Human virus</term>
<term>Human virus type</term>
<term>Immune</term>
<term>Immune activation</term>
<term>Immune activation markers</term>
<term>Marker</term>
<term>Median</term>
<term>Median levels</term>
<term>Median plasma</term>
<term>Mycobacterium tuberculosis</term>
<term>Neopterin</term>
<term>Outlier values</term>
<term>Placebo</term>
<term>Placebo group</term>
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<front><div type="abstract" xml:lang="en">We analyzed changes in plasma human immunodeficiency virus (HIV)‐1 viral load, CD4+ T‐cell count, and markers of immune activation markers at start of treatment of tuberculosis and 12 months after among 44 HIV‐1‐infected patients with newly diagnosed, sputum‐smear positive for Mycobacterium tuberculosis pulmonary in fection. All patients received a standard regimen of 6 months of rifampicin and isoniazid with first 2 months of pyrazinamid with or without cotrimoxazole. Compared with values at start of treatment, median viral load increased by a median of 0.64 log10 copies/ml after 12 months of follow‐up (P = 0.0002). Median CD4+ T‐cell counts were 393 cells/L at start of treatment and 370 cells/L after 12 months of follow‐up (P = 0.61). Levels of serum activation markers decreased significantly at 12 months of follow‐up of the patients for both patients on standard and cotrimoxazole treatment. Levels of viral load, CD4+ T‐cell counts, and markers of immune activation were not different for patients on standard treatment of tuberculosis compared with those on standard and cotrimoxazole treatment. Levels of serum activation markers decreased significantly at 12 months of follow‐up of the patients for both patients on standard and cotrimoxazole treatment. Because viral load is a predictor of disease progression, its persistent elevated levels in blood of HIV‐infected patients co‐infected with tuberculosis, who successfully complete TB treatment, may account for the high mortality observed in this population. J. Med. Virol. 75:202–208, 2005. © 2004 Wiley‐Liss, Inc.</div>
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